The process of low temperature cofired ceramics fabrication includes a lamination step where pressure is applied during a certain time and at a certain temperature in order to create a monolithic block out of the green sheets before firing. This lamination can be done by the use of a uniaxial or an isostatic press. In this paper, we compare the two methods to determine if there is a difference in lamination quality and if the shrinkage after firing is impacted by the lamination method. The study is based on a design of experiments approach, where the four factors – stack thickness, surface area, lamination pressure and lamination temperature – are tested using an isostatic press. The result variables are lamination quality, vertical and lateral shrinkage. The findings are compared to a previous study where the same set of experiments was performed with a uniaxial press. It is found that the isostatic press allows for a better lamination quality for small surface area, high stack samples. Also, the isostatic lamination leads to less shrinkage variation. Finally, we present prediction models for the vertical and lateral shrinkage, that will allow the manufacturer to better predict and control the fabrication process.